A hyphema is a collection of blood within the anterior chamber of the eye. The blood often settles in the inferior portion of the chamber when a patient is upright making it easier to diagnose than when a patient is lying flat and the blood disperses. Hyphemas may be the result of non-penetrating trauma or may occur spontaneously, which is often associated with sickle cell anemia. Possible complications include increased ocular pressure, vision loss, staining of the cornea, atrophy, peripheral anterior synechiae, or recurrence of bleeding. Prompt ophthalmologic evaluation is important.